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When a client visits your practice concerned and complaining about their dog’s “accidents” at night, urinary incontinence (UI) due to urethral sphincter hypotonus likely jumps to mind. Upgrade your patients to a more advanced UI treatment with PROIN ER™ (phenylpropanolamine hydrochloride extended-release tablets). It’s an effective, once-daily treatment that helps improve patient response and client compliance. Here’s how.

Consistent response

PROIN ER™ features patented extended-release technology that allows for once-daily dosing, rather than requiring clients to give multiple tablets per day. It features the same trusted active ingredient as PROIN® with the added benefit of prolonged release, which minimizes fluctuations in blood levels.  

“Some dogs, especially those that might have some appetite issues or get a little agitated right after their PROIN dose, have a bit smoother experience with the once-daily dose of PROIN ER,” says Julie Byron, DVM, MS, DACVIM, professor of Clinical Small Animal Internal Medicine at The Ohio State University College of Veterinary Medicine. “Without the spikes in medication throughout the day, I find that clients notice a difference in their dog’s behaviors. For example, when a dog switches to PROIN ER, the client might say, ‘You know, she seems a bit calmer now. More like herself.’ And that’s a positive of PROIN ER.”

Preferred by dog owners

A recent survey found that 97% of dog owners prefer giving one tablet a day rather than multiple tablets.* The convenience of once-daily dosing with PROIN ER™ increases the likelihood clients will properly medicate, which helps improve client compliance and, thus, patient outcomes.

In addition to improving clients’ compliance, PROIN ER™ can help improve the human animal bond. It reduces the frustration of constant cleanup and, perhaps more importantly, the worry that their dog isn’t living a good life.

“Clients hate the idea of having to medicate their pet multiple times a day with any medication,” said Dr. Byron. “Some clients might decide to let their dog go because they feel like quality of life is poor for their dog and for them because they’re medicating three times a day. PROIN ER™ being a once-a-day medication helps with that issue.”

Reliable treatment

As the only FDA-approved once-daily treatment for the control of urinary incontinence due to urethral sphincter hypotonus in dogs, PROIN ER™ is proven safe and effective. It is labeled for dosing in four weight-based strengths, which allows for accurate dosage of virtually any sized dog weighing 10 pounds or more.

“Because PROIN ER has such a high effectiveness rate, if a patient isn’t responding, I may start to question whether that dog is actually experiencing UI due to sphincter hypotonus,” said Dr. Byron. 

With PROIN ER™ you get a simple, once-a-day way to elevate your practice and help improve patient outcomes. When you add the benefit of freeing clients from giving multiple pills a day, PROIN ER™ provides a trusted option for getting people and dogs back to more positive moments together.

IMPORTANT SAFETY INFORMATION: For oral use in dogs only. Not for human use. Keep out of reach of children. If accidentally ingested by humans, contact a physician immediately. The most commonly reported side effects were vomiting, loss of appetite, diarrhea, excessive salivation, agitation, tiredness, vocalization, confusion, increased water consumption, weight loss, weakness, fever, panting, and reversible changes in skin color (flushing or bright pink). Abnormal gait, seizures or tremors, as well as liver enzyme elevations, kidney failure, blood in urine and urine retention have been reported. In some cases death, including euthanasia has been reported. Sudden death was sometimes preceded by vocalization or collapse.

Instances of dogs chewing through closed vials of PROIN® and eating the vial contents have been reported, in some cases resulting in overdose. Keep the product in a secured storage area out of the reach of pets in order to prevent accidental ingestion or overdose, as dogs may willingly consume more than the recommended dosage of PROIN® Chewable Tablets or PROIN ER™ tablets. Contact your veterinarian immediately if the dog ingests more tablets than prescribed or if other pets ingest PROIN Chewable tablets or PROIN ER tablets.

PROIN and PROIN ER may cause elevated blood pressure and should be used with caution in dogs with pre-existing heart disease, high blood pressure, liver disease, kidney insufficiency, diabetes, glaucoma, and other conditions associated with high blood pressure. Dogs may transition from PROIN Chewable Tablets to PROIN ER without a break in administration. However, do not alternate PROIN ER with PROIN Chewable Tablets because the effectiveness and safety of interchangeable use have not been evaluated.

The safe use of PROIN and PROIN ER in dogs used for breeding purposes, during pregnancy or in lactating bitches, has not been evaluated. Contact your veterinarian if you notice restlessness or irritability, loss of appetite, the incontinence persists or worsens, or any other unusual signs. See prescribing information for complete details regarding adverse events, warning and precautions or visit prnpharmacal.com.

*Consumer Dog Owner survey conducted by PRN Pharmacal, December 2022.

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