Denamarin for dogs and cats provides a multi-faceted approach to liver support. Denamarin combines anti-oxidant S-Adenosylmethionine (SAM-e) with silybin complex for beneficial effects on liver function. SAM-e has been shown to increase hepatic glutathione levels. Glutathione is a potent antioxidant that protects hepatic cells from toxins and death. SAM-e has also been shown to protect liver cells from cell death and may be useful in cell regeneration. Silybin is derived from milk thistle. It supports oxidative balance and helps the flow of bile through the liver. Silybin may also support levels of glutathione which is an important compound protecting liver health.